研究・業績

2013年

1. Sunbul M, Sugiyama M, Kurbanov F, Leblebicioglu H, Khan A, Elkady A, Tanaka Y, Mizokami M. Specific Mutations of Basal Core Promoter Are Associated with Chronic Liver Disease in Hepat itis B Virus Subgenotype D1 Prevalent in Turkey. Microbiol Immunol 57 (2): 122-9 2013.02

2. Sakamoto T, Tanaka Y, Watanabe T, Iijima S, Kani S, Sugiyama M, Murakami S, Matsuura K, Kusakabe A, Shinkai N, Sugauchi F, Mizokami M. Mechanism of the Dependence of Hepat itis B Virus Genotype G on Co-Infection with Other Genotypes for Viral Rep lication. J Viral Hepat 20 (4): e27-36 2013.04

3. Sunbul M, Khan A, Kurbanov F, Leblebicioglu H, Sugiyama M, Tanaka Y, Mizokami M. Tracing the Spread of Hepat itis C Virus in Turkey: A Phylogenetic Analysis. Int ervirology 56 (3): 201-5 2013.04

4. Yoshio S, Kanto T, Kuroda S, Matsubara T, Higashitani K, Kakita N, Ishida H, Hiramatsu N, Nagano H, Sugiyama M, Murata K, Fukuhara T, Matsuura Y, Hayashi N, Mizokami M, Takehara T. Human Blood Dendritic Cell Antigen 3 (Bdca3)(+) Dendritic Cells Are a Potent Producer of Int erferon-Lambda in Response to Hepat itis C Virus. Hepatology 57 (5): 1705-15 2013.05

5. Awata T, Yamashita H, Kurihara S, Morita-Ohkubo T, Miyashita Y, Katayama S, Kawasaki E, Tanaka S, Ikegami H, Maruyama T, Shimada A, Takahashi K, Kawabata Y, Kobayashi T, Nishida N, Mawatari Y. A Low-Frequency Glis3 Variant Associated with Resistance to Japanese Type 1 Diabetes. Biochem Biophys Res Commun 437 (4): 521-5 2013.08.9

6. Watanabe T, Sugauchi F, Tanaka Y, Matsuura K, Yatsuhashi H, Murakami S, Iijima S, Iio E, Sugiyama M, Shimada T, Kakuni M, Kohara M, Mizokami M. Hepat itis C Virus Kinetics by Administration of Pegylated Int erferon-Alpha in Human and Chimeric Mice Carrying Human Hepat ocytes with Variants of the Il28b Gene. Gut 62 (9): 1340-6 2013.09

9. Korenaga K, Korenaga M, Teramoto F, Suzuki T, Nishina S, Sasaki K, Nakashima Y, Tomiyama Y, Yoshioka N, Hara Y, Moriya T, Hino K.Clinical Usefulness of Non-Protein Respiratory Quotient Measurement in Non-Alcoholic Fatty Liver Disease. Hepatol Res 43 (12): 1284-94 2013.12

共著論文

1. Rawal RK, Singh US, Chavre SN, Wang J, Sugiyama M, Hung W, Govindarajan R, Korba B, Tanaka Y, Chu CK.2'-Fluoro-6'-Methylene-Carbocyclic Adenosine Phosphoramidate (Fmcap) Prodrug: In Vitro Anti-Hbv Activity against the Lamivudine-Entecavir Resistant Triple Mutant and Its Mechanism of Action. Bioorg Med Chem Lett 23 (2): 503-6 2013.01.15

2. Kuno A, Ikehara Y, Tanaka Y, Ito K, Matsuda A, Sekiya S, Hige S, Sakamoto M, Kage M, Mizokami M, Narimatsu H. A Serum "Sweet-Doughnut" Protein Facilitates Fibrosis Evaluation and Therapy Assessment in Patients with Viral Hepat itis. Sci Rep 3 (1065): 1-9 2013.01.17

3. Miyagi Y, Nomura H, Yamashita N, Tanimoto H, Ito K, Masaki N, Mizokami M, Shibuya T. Estimation of Two Real-Time Rt-Pcr Assays for Quantitation of Hepat itis C Virus Rna During Peg-Ifn Plus Ribavirin Therapy by Hcv Genotypes and Il28b Genotype. J Infect Chemother 19 (1): 63-9 2013.02

4. Miyazaki T, Arihiro S, Mitobe J, Aoki Y, Takikawa S, Saruta M, Matsuoka M, Koike K, Kato T, Kashiwagi H, Ikegami M, Tajiri H. The Utility of Balloon Enteroscopy in the Diagnosis of Histiocytic Sarcoma of the Small Int estine: A Case Rep ort. Pathol Int 63 (2): 120-4 2013.02

5. Kawamura Y, Takahashi T, Liu X, Nishida N, Tokunaga K, Ukawa K, Noda Y, Yoshikawa A, Shimada T, Umekage T, Sasak T. DNA Polymorphism in the Fkbp5 Gene Affects Impulsivity in Int ertemporal Choice. Asia Pac Psychiatry 5 (1): 31-8 2013.03

6. Kurosaki M, Tanaka Y, Nishida N, Sakamoto N, Enomoto N, Matsuura K, Asahina Y, Nakagawa M, Watanabe M, Sakamoto M, Maekawa S, Tokunaga K, Mizokami M, Izumi N. Model Incorporating the Itpa Genotype Identifies Patients at High Risk of Anemia and Treatment Failure with Pegylated-Int erferon Plus Ribavirin Therapy for Chronic Hepat itis C. J Med Virol 85 (3): 449-58 2013.03

7. Nakagawa M, Sakamoto N, Watanabe T, Nishimura-Sakurai Y, Onozuka I, Azuma S, Kakinuma S, Nitta S, Kiyohashi K, Kusano-Kitazume A, Murakawa M, Yoshino K, Itsui Y, Tanaka Y, Mizokami M, Watanabe M, Ochanomizu-Liver Conference S. Association of Itpa Gene Variation and Serum Ribavirin Concentration with a Decline in Blood Cell Concentrations During Pegylated Int erferon-Alpha Plus Ribavirin Therapy for Chronic Hepat itis C. Hepat ology Int ernational 7 (1): 153-161 2013.03

8. Harada N, Hiramatsu N, Oze T, Yamada R, Kurokawa M, Miyazaki M, Yakushijin T, Miyagi T, Tatsumi T, Kiso S, Kanto T, Kasahara A, Oshita M, Mita E, Hagiwara H, Inui Y, Katayama K, Tamura S, Yoshihara H, Imai Y, Inoue A, Hayashi N, Takehara T. Incidence of Hepat ocellular Carcinoma in Hcv-Infected Patients with Normal Alanine Aminotransferase Levels Categorized by Japanese Treatment Guidelines. J Gastroenterol 48 (4): 535-43 2013.04

9. Matsubara T, Kanto T, Kuroda S, Yoshio S, Higashitani K, Kakita N, Miyazaki M, Sakakibara M, Hiramatsu N, Kasahara A, Tomimaru Y, Tomokuni A, Nagano H, Hayashi N, Takehara T. Tie2-Expressing Monocytes as a Diagnostic Marker for Hepat ocellular Carcinoma Correlates with Angiogenesis. Hepat ology 57 (4): 1416-25 2013.04

13. Nakagawa S, Hirata Y, Kameyama T, Tokunaga Y, Nishito Y, Hirabayashi K, Yano J, Ochiya T, Tateno C, Tanaka Y, Mizokami M, Tsukiyama-Kohara K, Inoue K, Yoshiba M, Takaoka A, Kohara M. Targeted Induction of Int erferon-Lambda in Humanized Chimeric Mouse Liver Abrogates Hepat otropic Virus Infection. PLoS One 8 (3): e59611 2013.04.5

10. Miyashita A, Koike A, Jun G, Wang LS, Takahashi S, Matsubara E, Kawarabayashi T, Shoji M, Tomita N, Arai H, Asada T, Harigaya Y, Ikeda M, Amari M, Hanyu H, Higuchi S, Ikeuchi T, Nishizawa M, Suga M, Kawase Y, Akatsu H, Kosaka K, Yamamoto T, Imagawa M, Hamaguchi T, Yamada M, Moriaha T, Takeda M, Takao T, Nakata K, Fujisawa Y, Sasaki K, Watanabe K, Nakashima K, Urakami K, Ooya T, Takahashi M, Yuzuriha T, Serikawa K, Yoshimoto S, Nakagawa R, Kim JW, Ki CS, Won HH, Na DL, Seo SW, Mook-Jung I, St George-Hyslop P, Mayeux R, Haines JL, Pericak-Vance MA, Yoshida M, Nishida N, Tokunaga K, Yamamoto K, Tsuji S, Kanazawa I, Ihara Y, Schellenberg GD, Farrer LA, Kuwano R. Sorl1 Is Genetically Associated with Late-Onset Alzheimer's Disease in Japanese, Koreans and Caucasians. PLoS One 8 (4): e58618 2013.04.09

11. Higashitani K, Kanto T, Kuroda S, Yoshio S, Matsubara T, Kakita N, Oze T, Miyazaki M, Sakakibara M, Hiramatsu N, Mita E, Imai Y, Kasahara A, Okuno A, Takikawa O, Hayashi N, Takehara T. Association of Enhanced Activity of Indoleamine 2,3-Dioxygenase in Dendritic Cells with the Induction of Regulatory T Cells in Chronic Hepat itis C Infection. J Gastroenterol 48 (5): 660-70 2013.05

12. Abe T, Hashiguchi A, Yamazaki K, Ebinuma H, Saito H, Kumada H, Izumi N, Masaki N, Sakamoto M. Quantification of Collagen and Elastic Fibers Using Whole-Slide Images of Liver Biopsy Specimens. Pathol Int 63 (6): 305-10 2013.06

13. Sakaki N, Ashida K, Mizokami Y, Chiba T, Matsui S, Kanto T, Uemura N, Hiramatsu N, Sugano K. Endoscopic Evaluation of Low-Dose Aspirin-Induced Gastric and Duodenal Ulcers During Prophylaxis with Lansoprazole. Hepat ogastroenterology 60 (124): 762-7 2013.06

14. Kaji H, Ocho M, Togayachi A, Kuno A, Sogabe M, Ohkura T, Nozaki H, Angata T, Chiba Y, Ozaki H, Hirabayashi J, Tanaka Y, Mizokami M, Ikehara Y, Narimatsu H. Glycoproteomic Discovery of Serological Biomarker Candidates for Hcv/Hbv Infection-Associated Liver Fibrosis and Hepat ocellular Carcinoma. J Proteome Res 12 (6): 2630-40 2013.06.7

15. Akkarathamrongsin S, Hacharoen P, Tangkijvanich P, Theamboonlers A, Tanaka Y, Mizokami M, Poovorawan Y. Molecular Epidemiology and Genetic History of Hepat itis C Virus Subtype 3a Infection in Thailand. Int ervirology 56 (5): 284-94 2013.07

16. Ishida H, Kato T, Takehana K, Tatsumi T, Hosui A, Nawa T, Kodama T, Shimizu S, Hikita H, Hiramatsu N, Kanto T, Hayashi N, Takehara T. Valine, the Branched-Chain Amino Acid, Suppresses Hepat itis C Virus Rna Rep lication but Promotes Infectious Particle Formation. Biochem Biophys Res Commun 437 (1): 127-33 2013.07.19

17. Watanabe K, Nagata N, Shimbo T, Nakashima R, Furuhata E, Sakurai T, Akazawa N, Yokoi C, Kobayakawa M, Akiyama J, Mizokami M, Uemura N. Accuracy of Endoscopic Diagnosis of Helicobacter Pylori Infection According to Level of Endoscopic Experience and the Effect of Training. BMC Gastroenterol 13: 128 2013.08.21

18. Ikeda M, Okahisa Y, Aleksic B, Won M, Kondo N, Naruse N, Aoyama-Uehara K, Sora I, Iyo M, Hashimoto R, Kawamura Y, Nishida N, Miyagawa T, Takeda M, Sasaki T, Tokunaga K, Ozaki N, Ujike H, Iwata N. Evidence for Shared Genetic Risk between Methamphetamine-Induced Psychosis and Schizophrenia. Neuropsychopharmacology 38 (10): 1864-70 2013.09

19. Aketa H, Tatsumi T, Kohga K, Tsunematsu H, Aono S, Shimizu S, Kodama T, Nawa T, Shigekawa M, Hikita H, Sakamori R, Hosui A, Miyagi T, Hiramatsu N, Kanto T, Hayashi N, Takehara T. The Combination Therapy of Alpha-Galactosylceramide and 5-Fluorouracil Showed Antitumor Effect Synergistically against Liver Tumor in Mice. Int J Cancer 133 (5): 1126-34 2013.09.1

20. Kanazawa T, Ikeda M, Glatt SJ, Tsutsumi A, Kikuyama H, Kawamura Y, Nishida N, Miyagawa T, Hashimoto R, Takeda M, Sasaki T, Tokunaga K, Koh J, Iwata N, Yoneda H. Genome-Wide Association Study of Atypical Psychosis. Am J Med Genet B Neuropsychiatr Genet 162 (7): 679-86 2013.10

21. Yotsuyanagi H, Ito K, Yamada N, Takahashi H, Okuse C, Yasuda K, Suzuki M, Moriya K, Mizokami M, Miyakawa Y, Koike K. High Levels of Hepat itis B Virus after the Onset of Disease Lead to Chronic Infection in Patients with Acute Hepat itis B. Clin Infect Dis 57 (7): 935-42 2013.10

22. Kodama T, Hikita H, Kawaguchi T, Saito Y, Tanaka S, Shigekawa M, Shimizu S, Li W, Miyagi T, Kanto T, Hiramatsu N, Tatsumi T, Takehara T. The Bcl-2 Homology Domain 3 (Bh3)-Only Proteins Bim and Bid Are Functionally Active and Restrained by Anti-Apoptotic Bcl-2 Family Proteins in Healthy Liver. J Biol Chem 288 (42): 30009-18 2013.10.18

23. Watashi K, Liang G, Iwamoto M, Marusawa H, Uchida N, Daito T, Kitamura K, Muramatsu M, Ohashi H, Kiyohara T, Suzuki R, Li J, Tong S, Tanaka Y, Murata K, Aizaki H, Wakita T. Int erleukin-1 and Tumor Necrosis Factor-Alpha Trigger Restriction of Hepat itis B Virus Infection Via a Cytidine Deaminase Activation-Induced Cytidine Deaminase (Aid). J Biol Chem 288 (44): 31715-27 2013.11.1

24. Michikawa T, Inoue M, Sawada N, Sasazuki S, Tanaka Y, Iwasaki M, Shimazu T, Yamaji T, Mizokami M, Tsugane S. Plasma Levels of Adiponectin and Primary Liver Cancer Risk in Middle-Aged Japanese Adults with Hepat itis Virus Infection: A Nested Case-Control Study. Cancer Epidemiol Biomarkers Prev 22 (12): 2250-7 2013.12

25. Nagata N, Niikura R, Shimbo T, Kishida Y, Sekine K, Tanaka S, Aoki T, Watanabe K, Akiyama J, Yanase M, Itoh T, Mizokami M, Uemura N. Alcohol and Smoking Affect Risk of Uncomplicated Colonic Diverticulosis in Japan. PLoS One 8 (12): e81137 2013.12

26. Trinks J, Sugiyama M, Tanaka Y, Kurbanov F, Benetucci J, Gimenez E, Weissenbacher MC, Mizokami M, Oubina JR. In Vitro Rep lication Competence of a Hepat itis B Genotype D/a Recombinant Virus: Dissimilar Biological Behaviour Regarding Its Parental Genotypes. J Gen Virol 94 Pt 12: 2724-8 2013.12

27. Kusumoto S, Tanaka Y, Mizokami M, Ueda R. Is Antiviral Prophylaxis Necessary to Prevent Hepat itis B Virus (Hbv) Reactivation in Patients with Hbv-Resolved Infection Receiving Rituximab-Containing Chemother apy J Clin Oncol 31 (35): 4480 2013.12.10

28. Khan A, Al Balwi MA, Tanaka Y, Hajeer A, Sanai FM, Al Abdulkarim I, Al Ayyar L, Badri M, Saudi D, Tamimi W, Mizokami M, Al Knawy B. Novel Point Mutations and Mutational Complexes in the Enhancer Ii, Core Promoter and Precore Regions of Hepat itis B Virus Genotype D1 Associated with Hepat ocellular Carcinoma in Saudi Arabia. Int J Cancer 133 (12): 2864-71 2013.12.15


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