研究・業績

2015年

1. Miyadera H, Ohashi J, Lernmark A, Kitamura T, Tokunaga K.  Cell-Surface Mhc Density Profiling Reveals Instability of Autoimmunity-Associated Hla.   J Clin Invest 125 (1): 275-91 2015.01 内容紹介

2. Sato I, Shimbo T, Kawasaki Y, Masaki NComparison of Peginterferon Alfa-2a and Alfa-2b for Treatment of Patients with Chronic Hepatitis C: A Retrospective Study Using the Japanese Interferon Database.   Drug Des Devel Ther 9: 283-290 2015.01.8

3. Masaki N, Shrestha PK, Nishimura S, Ito K, Sugiyama M, Mizokami MUse of Nucleoside Analogs in Patients with Chronic Hepatitis B in Nepal: A Prospective Cohort Study in a Single Hospital.   Hepatol Res: 2015.01.12

4. Takahashi H, Ikeda M, Kumada T, Osaki Y, Kondo S, Kusumoto S, Ohkawa K, Nadano S, Furuse J, Kudo M, Ito K, Yokoyama M, Okusaka T, Shimoyama M, Mizokami MMulticenter Cooperative Case Survey of Hepatitis B Virus Reactivation by Chemotherapeutic Agents.   Hepatol Res [Epub ahead of print]: 2015.01.27

5. Hiramine S, Sugiyama M, Furusyo N, Uto H, Ido A, Tsubouchi H, Watanabe H, Ueno Y, Korenaga M, Murata K, Masaki N, Hayashi J, Thomas DL, Mizokami MA Thymine-Adenine Dinucleotide Repeat Polymorphism near Il28b Is Associated with Spontaneous Clearance of Hepatitis C Virus.   J Gastroenterol: 2015.03.5

6. Korenaga M, Nishina S, Korenaga K, Tomiyama Y, Yoshioka N, Hara Y, Sasaki Y, Shimonaka Y, Hino K.  Branched-Chain Amino Acids Reduce Hepatic Iron Accumulation and Oxidative Stress in Hepatitis C Virus Polyprotein-Expressing Mice.   Liver Int 35 (4): 1303-14 2015.04

7.Mizokami M, Yokosuka O, Takehara T, Sakamoto N, Korenaga M, Mochizuki H, Nakane K, Enomoto H, Ikeda F, Yanase M, Toyoda H, Genda T, Umemura T, Yatsuhashi H, Ide T, Toda N, Nirei K, Ueno Y, Nishigaki Y, Betular J, Gao B, Ishizaki A, Omote M, Mo H, Garrison K, Pang PS, Knox SJ, Symonds WT, McHutchison JG, Izumi N, Omata M. Ledipasvir and sofosbuvir fixed-dose combination with and without ribavirin for 12 weeks in treatment-naive and previously treated Japanese patients with genotype 1 hepatitis C: an open-label, randomised, phase 3 trial. Lancet Infect Dis. 2015;15(6):645-53 内容紹介

8.Nishida N, Ohashi J, Sugiyama MTsuchiura T, Yamamoto K, Hino K, Honda M, Kaneko S, Yatsuhashi H, Koike K, Yokosuka O, Tanaka E, Taketomi A, Kurosaki M, Izumi N, Sakamoto N, Eguchi Y, Sasazuki T, Tokunaga K, Mizokami M. Effects of HLA-DPB1 genotypes on chronic hepatitis B infection in Japanese individuals. Tissue Antigens 2015 内容紹介

9.Miyadera H, Bungener LB, Kusano S, Yokoyama S, Tokunaga K, Hepkema BG. Questionable expression of unstable DQ heterodimer containing HLA-DQA1*01:07. Tissue Antigens. 86(6):413-8. 2015.12

共著論文

1. Toshima T, Shirabe K, Ikegami T, Yoshizumi T, Kuno A, Togayachi A, Gotoh M, Narimatsu H, Korenaga M, Mizokami M, Nishie A, Aishima S, Maehara Y.  A Novel Serum Marker, Glycosylated Wisteria Floribunda Agglutinin-Positive Mac-2 Binding Protein (Wfa(+)-M2bp), for Assessing Liver Fibrosis.   J Gastroenterol 50 (1): 76-84 2015.01

2. Tamaki N, Kurosaki M, Kuno A, Korenaga M, Togayachi A, Gotoh M, Nakakuki N, Takada H, Matsuda S, Hattori N, Yasui Y, Suzuki S, Hosokawa T, Tsuchiya K, Nakanishi H, Itakura J, Takahashi Y, Mizokami M, Narimatsu H, Izumi N.  Wisteria Floribunda Agglutinin Positive Human Mac-2-Binding Protein as a Predictor of Hepatocellular Carcinoma Development in Chronic Hepatitis C Patients.   Hepatol Res: 2015.01.6

3. Nagata N, Niikura R, Aoki T, Shimbo T, Sekine K, Okubo H, Watanabe K, Sakurai T, Yokoi C, Akiyama J, Yanase M, Mizokami M, Uemura N.  Impact of Discontinuing Non-Steroidal Antiinflammatory Drugs on Long-Term Recurrence in Colonic Diverticular Bleeding.   World J Gastroenterol 21 (4): 1292-8 2015.01.28

4. Totani H, Kusumoto S, Ishida T, Masuda A, Yoshida T, Ito A, Ri M, Komatsu H, Murakami S, Mizokami M, Ueda R, Niimi A, Inagaki H, Tanaka Y, Iida S.  Reactivation of Hepatitis B Virus (Hbv) Infection in Adult T-Cell Leukemia-Lymphoma Patients with Resolved Hbv Infection Following Systemic Chemotherapy.   Int J Hematol: 2015.01.30

5. Ikeda M, Yoshimura R, Hashimoto R, Kondo K, Saito T, Shimasaki A, Ohi K, Tochigi M, Kawamura Y, Nishida N, Miyagawa T, Sasaki T, Tokunaga K, Kasai K, Takeda M, Nakamura J, Ozaki N, Iwata N.  Genetic Overlap between Antipsychotic Response and Susceptibility to Schizophrenia.   J Clin Psychopharmacol 35 (1): 85-8 2015.02

6. Nagata N, Niikura R, Aoki T, Shimbo T, Kishida Y, Sekine K, Tanaka S, Okubo H, Watanabe K, Sakurai T, Yokoi C, Akiyama J, Yanase M, Mizokami M, Uemura N.  Natural History of Outpatient-Onset Ischemic Colitis Compared with Other Lower Gastrointestinal Bleeding: A Long-Term Cohort Study.   Int J Colorectal Dis 30 (2): 243-9 2015.02

7. Nagata N, Niikura R, Sekine K, Sakurai T, Shimbo T, Kishida Y, Tanaka S, Aoki T, Okubo H, Watanabe K, Yokoi C, Akiyama J, Yanase M, Mizokami M, Uemura N.  Risk of Peptic Ulcer Bleeding Associated with Helicobacter Pylori Infection, Nonsteroidal Anti-Inflammatory Drugs, Low-Dose Aspirin, and Antihypertensive Drugs: A Case-Control Study.   J Gastroenterol Hepatol 30 (2): 292-8 2015.02

8. Nagata N, Niikura R, Shimbo T, Ishizuka N, Yamano K, Mizuguchi K, Akiyama J, Yanase M, Mizokami M, Uemura N.  High-Dose Barium Impaction Therapy for the Recurrence of Colonic Diverticular Bleeding: A Randomized Controlled Trial.   Ann Surg 261 (2): 269-75 2015.02

9. Aoki T, Nagata N, Sakamoto K, Arai T, Niikura R, Shimbo T, Shinozaki M, Sekine K, Okubo H, Watanabe K, Sakurai T, Yokoi C, Akiyama J, Yanase M, Mizokami M, Noda M, Uemura N.  Abdominal Fat Accumulation, as Measured by Computed Tomography, Increases the Risk of Ischemic Colitis: A Retrospective Case-Control Study.   Dig Dis Sci: 2015.02.4

10. Tsukuda S, Watashi K, Iwamoto M, Suzuki R, Aizaki H, Okada M, Sugiyama M, Kojima S, Tanaka Y, Mizokami M, Li J, Tong S, Wakita T.  Dysregulation of Retinoic Acid Receptor Diminishes Hepatocyte Permissiveness to Hepatitis B Virus Infection through Modulation of Sodium Taurocholate Cotransporting Polypeptide (Ntcp) Expression.   J Biol Chem 290 (9): 5673-84 2015.02.27

11. Aoki T, Nagata N, Niikura R, Shimbo T, Tanaka S, Sekine K, Kishida Y, Watanabe K, Sakurai T, Yokoi C, Akiyama J, Yanase M, Mizokami M, Uemura N.  Recurrence and Mortality among Patients Hospitalized for Acute Lower Gastrointestinal Bleeding.   Clin Gastroenterol Hepatol 13 (3): 488-494 e1 2015.03

12. Iio E, Matsuura K, Nishida N, Maekawa S, Enomoto N, Nakagawa M, Sakamoto N, Yatsuhashi H, Kurosaki M, Izumi N, Hiasa Y, Masaki N, Ide T, Hino K, Tamori A, Honda M, Kaneko S, Mochida S, Nomura H, Nishiguchi S, Okuse C, Itoh Y, Yoshiji H, Sakaida I, Yamamoto K, Watanabe H, Hige S, Matsumoto A, Tanaka E, Tokunaga K, Tanaka Y.  Genome-Wide Association Study Identifies a Psmd3 Variant Associated with Neutropenia in Interferon-Based Therapy for Chronic Hepatitis C.   Hum Genet 134 (3): 279-89 2015.03

13. Niikura R, Nagata N, Aoki T, Shimbo T, Tanaka S, Sekine K, Kishida Y, Watanabe K, Sakurai T, Yokoi C, Yanase M, Akiyama J, Mizokami M, Uemura N.  Predictors for Identification of Stigmata of Recent Hemorrhage on Colonic Diverticula in Lower Gastrointestinal Bleeding.   J Clin Gastroenterol 49 (3): e24-30 2015.03

14. Nagata N, Niikura R, Aoki T, Moriyasu S, Sakurai T, Shimbo T, Sekine K, Okubo H, Watanabe K, Yokoi C, Akiyama J, Yanase M, Mizokami M, Fujimoto K, Uemura N.  Risk factors for adverse in-hospital outcomes in acute colonic diverticular hemorrhage.  World J Gastroenterol. 7;21(37):10697-703. 2015.10

15. Fujiyoshi M, Kuno A, Gotoh M, Fukai M, Yokoo H, Kamachi H, Kamiyama T, Korenaga M, Mizokami M, Narimatsu H, Taketomi A.  Clinicopathological characteristics and diagnostic performance of Wisteria floribunda agglutinin positive Mac-2-binding protein as a preoperative serum marker of liver fibrosis in hepatocellular carcinoma.  J Gastroenterol,50,(11), 1134-44, 2015. 11

16. Nagata N, Sakamoto K, Arai T, Niikura R, Shimbo T, Shinozaki M, Aoki T, Sekine K, Okubo H, Watanabe K, Sakurai T, Yokoi C, Akiyama J, Yanase M, Noda M, Itoh T, Mizokami M, Uemura N.  Visceral Abdominal Obesity Measured by  Computed Tomography is Associated With Increased Risk of Colonic Diverticulosis.  J Clin Gastroenterol,49,(10), 816-22, 2015. 11

17. Khor SS, Yang W, Kawashima M, Kamitsuji S, Zheng X, Nishida N, Sawai H, Toyoda H, Miyagawa T, Honda M, Kamatani N, Tokunaga K. High-accuracy imputation for HLA class I and II genes based on high-resolution SNP data of population-specific references.
Pharmacogenomics J. 15(6):530-7. 2015. 12

18. Nozaki Y, Fujita K, Wada K, Yoneda M, Shinohara Y, Imajo K, Ogawa Y, Kessoku T, Nakamuta M, Saito S, Masaki N, Nagashima Y, Terauchi Y, Nakajima A. Deficiency of eNOS exacerbates early-stage NAFLD pathogenesis by changing the fat distribution. BMC Gastroenterol. 17;15:177. 2015.12


国立国際医療研究センター
肝炎・免疫研究センター
肝疾患研究部

〒272-8516 千葉県市川市国府台1-7-1
電話番号 047-372-3501/FAX 047-375-4766